 | 1. San Francisco 49ers, Week 6 |
| The Giants took a 26-3 victory in San Francisco vs. the eventual NFC Champions thanks to a strong defensive effort. |
| WATCH: COACH REACTION | READ: GAME RECAP |
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 | 2. Green Bay Packers, Week 12 |
| Coming out of the bye week, the Giants defeated the Packers, who would become the NFC's No.3 seed at 11-5. |
| WATCH: POSTGAME CELEBRATION | READ: GAME RECAP |
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 | 3. Washington Redskins, Weeks 7 and 13 |
| The season series was split between the Giants and the NFC East winners, with both games coming down to the final possession. |
| WATCH: WEEK 7 HIGHLIGHTS | LOCKER ROOM |
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 | 4. Week 15, Atlanta Falcons |
| The team that finished with the NFC's best regular season record shutout the Giants 34-0 in Atlanta. |
| WATCH: MANNING REACTION | READ: GAME RECAP |
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 | 5. Week 16, Baltimore Ravens |
| The Super Bowl XLVII champs gave the Giants' playoff hopes a crushing blow in Baltimore. |
| WATCH: COUGHLIN POSTGAME | READ: GAME RECAP |