The New York Giants began their second day of the draft with a trade. Tennessee traded the first pick in the second round (No. 33 overall) to Big Blue for its 40th, 108th and 245th picks. With the move up, the Giants selected Alabama safety Landon Collins.
| YEAR | RD | #(OVR) | PLAYER | POS | SCHOOL | PICK TRADE |
| 2015 | 2 | 1(33) | Landon Collins | Safety | Alabama | Tennessee traded the first pick in the second round (No. 33 overall) to Big Blue for its 40th, 108th and 245th picks. With the move up, the Giants selected Alabama safety Landon Collins. |
| 2013 | 4 | 13(110) | Ryan Nassib | QB | Syracuse | Giants traded up from No. 116 to Cardinals' No. 110 for a sixth-round selection |
| 2009 | 2 | 13(45) | Clint Sintim | OLB | Virginia | Saints traded 2nd and 5th round selections to Giants for Jeremy Shockey |
| 2009 | 3 | 21(85) | Ramses Barden | WR | Cal Poly | Eagles traded this selection to the Giants for 3rd and 5th round picks |
| 2009 | 5 | 15(151) | Rhett Bomar | QB | Sam Houston St. | 5th round selection from New Orleans in the Shockey trade |
| 2008 | 4 | 24(123) | Bryan Kehl | OLB | BYU | Giants swapped picks with Pittsburgh by giving up a 6th round selection |
| 2006 | 1 | 32(32) | Mathias Kiwanuka | DE | Boston College | from Pittsburgh |
| 2006 | 2 | 12(44) | Sinorice Moss | WR | Miami (FL) | from Baltimore |
| 2006 | 3 | 32(96) | Gerris Wilkinson | LB | Georgia Tech | from Pittsburgh |
| 2006 | 4 | 32(129) | Guy Whimper | OT | East Carolina | from Pittsburgh |
| 2004 | 1 | 1(1) | Eli Manning | QB | Mississippi | Giants traded QB Philip Rivers (4th overall), 2004 3rd-round pick, 2005 1st and 5th-round picks |
| 2002 | 1 | 14(14) | Jeremy Shockey | TE | Miami (FL) | from Tennessee |
| 2001 | 1 | 22(22) | Will Allen | DB | Syracuse | from Indianapolis |
| 1989 | 3 | 8(64) | Bob Kratch | OG | Iowa | from San Diego |
| 1989 | 4 | 9(93) | Lewis Tillman | RB | Jackson State | from San Diego |
| 1986 | 2 | 17(44) | Mark Collins | DB | Cal State Fullerton | from San Diego |
| 1986 | 2 | 24(51) | Pepper Johnson | LB | Ohio State | from Denver |
| 1986 | 2 | 26(53) | Greg Lasker | DB | Arkansas | from L.A. Raiders |
| 1984 | 4 | 21(105) | Gary Reasons | LB | Northwestern St. | from Denver |
| 1983 | 3 | 7(63) | Jamie Williams | TE | Nebraska | from San Francisco through L.A. Rams |
| 1983 | 12 | 2(309) | Robbie Jones | LB | Alabama | from Houston |
| 1981 | 8 | 28(221) | Bill Ard | OG | Wake Forest | from Oakland |
