The New York Giants take on the Buffalo Bills in Highmark Stadium for their fourth prime-time matchup of the season on Sunday, Oct. 15. Kickoff is set for 8:20 p.m. ET on NBC.
The Giants look to tie the regular-season series with the Bills, holding a 6-7 record in 13 contests. The teams have also met once in the postseason, when the Giants defeated Buffalo, 20-19, in Super Bowl XXV. The Bills won the most recent meeting, 28-14, on Sept. 15, 2019 in MetLife Stadium.
The Giants have won their last three games in Buffalo in 1999, 2007 and 2015. They last played in Buffalo on Oct. 4, 2015, when QB Eli Manning threw three touchdown passes in a 24-10 Giants victory
HOW TO WATCH GIANTS VS. BILLS ON TV
Channel: NBC
Announcers: Mike Tirico (Play-by-Play), Cris Collinsworth (Analyst), Melissa Stark (Reporter)
Postgame: Giants Postgame Live presented by Moderna on MSG Networks, YouTube, Giants.com, Giants App, and Giants TV
HOW TO LISTEN TO GIANTS VS. BILLS ON RADIO
Channel: WFAN 101.9FM & 660 AM
Play-by-Play: Bob Papa
Analyst: Carl Banks
Sideline: Howard Cross
Pre- and Postgame: John Schmeelk, Jonathan Casillas
Pregame: Giants Gameday begins at 6:20 p.m.
Postgame: Giants Extra Point presented by Pepsi.
GIANTS EN ESPAÑOL
Channel: WADO 1280 AM (Presentado por Ford)
Play-by-Play: Nestor Rosario
Analyst: Francis Adames
Giants App
Download the Giants' official app for iPhone, iPad and Android devices
HIGHLIGHTS FROM THE GAME
Find all of the big plays and important action from this clash on:
View rare photos of the all-time series between the New York Giants and Buffalo Bills.
New York Giants quarterback Jeff Hostetler (15) celebrates a second quarter touchdown against the Buffalo Bills during Super Bowl XXV in Tampa, Fla., in this Jan. 27, 1991 photo. The Giants, back at the spot where they won the Super Bowl a decade ago, began practice Monday Jan. 22, 2001 for this year's championship against the Baltimore Ravens. (AP Photo)
Lloyd Pate of the Buffalo Bills is caught in a pocket of New York Giants after gaining five yards in the first half of a game at Yankee Stadium in New York, Dec. 6, 1970. The Giants stopping Pate are Jim Files (58) left and Matt Hazeltine (64). The Giants won, 20-6. (AP Photo/J. Spencer Jones)
New York Giants' running back Tucker Frederickson (24) tries to make it through a monetary hole in the Buffalo Bill's line during game at New York's Yankee Stadium on Sunday, Dec. 7, 1970. Bills' end Ron McDole (72), coming off a block by New York offensive tackle Dick Buzin (77), tries to plug the hole. Giants guard Doug Van Horn (63) blocks Buffalo middle linebacker Edgard Chandler (52) at right. Fredrickson made gain of 2 yards on the play as New York won, 20-8. (AP Photo)
George Hunt (9) of the New York Giants gives the ball a well aimed kick over the reach of Dwight Harrison (28) of the Buffalo Bills in Buffalo, N.Y., Oct. 21, 1975. Harrison is knocked by Giants linebacker Brian Kelley (55). Hunt's 37-yard kick scored the winning field goal for the Giants, upsetting the Bills 17-14. (AP Photo/Jim McKnight)
New York Giants coach Bill Parcells is carried on the shoulders of Lawrence Taylor (56) and Carl Banks (58) after winning the Super Bowl XXV in Tampa, Fla., Sunday, Jan. 28, 1991. The Giants defeated the Buffalo Bills, 20-19. (AP Photo/Ed Reinke)
New York Giants running back Dave Meggett (30) carries the ball while in pursuit by Buffalo Bills cornerback Nate Odomes (37) during Super Bowl XXV in Tampa, FL, Jan. 27, 1991. The Giants defeated the Bills 20-19. (Paul Spinelli via AP)
New York Giants quarterback Jeff Hostetler (15) watches as running back Ottis Anderson (24) carries the ball against the Buffalo Bills during Super Bowl XXV in Tampa, FL, Jan. 27, 1991. The Giants defeated the Bills 20-19. (Paul Spinelli via AP)
New York Giants quarterback Jeff Hostetler (15) gets set for the next snap against the Buffalo Bills during Super Bowl XXV in Tampa, FL, Jan. 27, 1991. The Giants defeated the Bills 20-19. (Paul Spinelli via AP)
New York Giants wide receiver Mark Ingram (82) carries the ball against the Buffalo Bills during Super Bowl XXV in Tampa, FL, Jan. 27, 1991. The Giants defeated the Bills 20-19. (Paul Spinelli via AP)
New York Giants quarterback Jeff Hostetler (15) and tackle John Stuart "Jumbo" Elliott (76) look on as running back Ottis Anderson (24) carries the ball against the Buffalo Bills during Super Bowl XXV in Tampa, FL, Jan. 27, 1991. The Giants defeated the Bills 20-19. (Paul Spinelli via AP)
Buffalo Bills defensive end Bruce Smith (78) tries to fight his way past New York Giants offensive tackle John Elliott (76) during Super Bowl XXV in Tampa, FL, Jan. 27, 1991. The Giants defeated the Bills 20-19. (Paul Spinelli via AP)
New York Giants running back Ottis Anderson (24) carries the ball against the Buffalo Bills during Super Bowl XXV in Tampa, FL, Jan. 27, 1991. The Giants defeated the Bills 20-19. (Paul Spinelli via AP)
Buffalo Bills defensive back Dwight Drane (45) tries to chase down New York Giants running back Ottis Anderson (24) during Super Bowl XXV in Tampa, FL, Jan. 27, 1991. The Giants defeated the Bills 20-19. (Paul Spinelli via AP)
New York Giants wide receiver Stephen Baker (85) is taken down by Buffalo Bills cornerback Kirby Jackson (47) during Super Bowl XXV in Tampa, Fla., Jan. 27, 1991. The Giants won the Super Bowl, 20-19. (Paul Spinelli via AP)
New York Giants center Bart Oates (65) and guard William Roberts (66) in action against Buffalo Bills nose tackle Jeff Wright (91) during Super Bowl XXV in Tampa, FL, Jan. 27, 1991. The Giants defeated the Bills 20-19. (Paul Spinelli via AP)
New York Giants quarterback Jeff Hostetler runs from the field carrying the game winning ball overhead after his team beat the Buffalo Bills 20-19 in Super Bowl XXV in Tampa, Fla. It was the closest margin of victory in any of the Super Bowls. (AP Photo/Ron Heflin)
Leonard Marchall (70) and Erik Howard (74) of the New York Giants celebrate the sack of Buffalo Bills quarterback Jim Kelly (12) in the third quarter of SUper Bowl XXV Sunday, Jan. 27, 1991 in Tampa. (AP Photo/Lynn Sladky)
Buffalo Bills quarterback Jim Kelly gets sacked during the fourth quarter ny New York Giants linebacker Pepper Johnson. The Giants came out on top to win the Super Bowl 20-19 in Tampa Sunday, Jan. 27, 1991. (AP Photo/Bill Waugh)
New York Giants running back Ottis Anderson (24) carries the ball as he leaps over Buffalo Bills Kirby Jackson during fourth quarter of Super Bowl XXV at Tampa Stadium Sunday, Jan. 27, 1991. Giants Stephen Baker is under Jackson. The Giants defeated the Bills 20-19. (AP Photo/Bill Haber)
Buffalo Bills kicker Scott Norwood, center, misses the field goal on the last play of the game, clinching the victory for the New York Giants in Super Bowl XXV in Tampa Sunday, January 27, 1991. The Giants won 20-19. (AP Photo/Phil Sandlin)
New York Giants quarterback Jeff Hostetler (15) celebrates a second quarter touchdown against the Buffalo Bills during Super Bowl XXV in Tampa, Fla., in this Jan. 27, 1991 photo. The Giants, back at the spot where they won the Super Bowl a decade ago, began practice Monday Jan. 22, 2001 for this year's championship against the Baltimore Ravens. (AP Photo)
Buffalo Bills quarterback Doug Flutie (7) fumbles as he is taken down by New York Giants defensive end Cedric Jones (94) during the first half of the game at Ralph Wilson Stadium, in Orchard Park, N.Y., Sunday, Dec. 12, 1999. The Giants recovered the fumble that set up a field goal. They went on to beat the Bills 19-17. (AP Photo/Mike Groll)
New York Giants running back Tiki Barber (21) is stopped by Buffalo Bills defenders, from left, London Fletcher, Lawyer Milloy and Keith McKenzie during the third quarter Sunday, Nov. 30, 2003 in East Rutherford, N.J. Barber only managed 20 yards for the game in the Giants' 24-7 loss. (AP Photo/Julie Jacobson)
New York Giants' wide receiver Amani Toomer, left, catches a pass downfield for a touchdown in front of Buffalo Bills' London Fletcher during the second quarter Sunday, Nov. 30, 2003, in East Rutherford, New Jersey. (AP Photo/Julie Jacobson)
New York Giants' Brandon Jacobs (27) runs against the Buffalo Bills during the second half of an NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. The Giants won 38-21. (AP Photo/Derek Gee)
Buffalo Bills quarterback Trent Edwards, left, gets a pass off before being tackled by New York Giants safety Michael Johnson, right, during the first half of an NFL football game in Orchard Park, N.Y. on Sunday, Dec. 23, 2007. New York won 38-21. (AP Photo/Don Heupel)
New York Giants linebacker Kawika Mitchell, left, intercepts a pass intended for Buffalo Bills wide receiver Lee Evans, right, during the second half of an NFL football game in Orchard Park, N.Y. on Sunday, Dec. 23, 2007. Mitchell scored a touchdown on the play as New York defeated Buffalo 38-21. (AP Photo/Don Heupel)
Buffalo Bills punter Brian Moorman, right, tries to recover his fumble as New York Giants special teams player Ahmad Bradshaw, left, tackles him during the first half of an NFL football game in Orchard Park, N.Y. on Sunday, Dec. 23, 2007. New York won 38-21. (AP Photo/Don Heupel)
New York Giants quarterback Eli Manning looks to throw during the first quarter of the NFL football game against the Buffalo Bills at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/David Duprey)
New York Giants' Brandon Jacobs (27) scores a touchdown under pressure from Buffalo Bills' John DiGiorgio (52) during the second quarter of their NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. The Giants won 38-21. (AP Photo/Derek Gee)
New York Giants' Ahmad Bradshaw (44) runs past Buffalo Bills' Terrence McGee (24) for a touchdown during the second half of an NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/Derek Gee)
New York Giants' Amani Toomer (81) makes a catch under pressure from Buffalo Bills' Jim Leonhard (42) during the first quarter of the NFL football at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. (AP Photo/Derek Gee)
New York Giants' Ahmad Bradshaw (44) is hit by Buffalo Bills' Bryan Scott (43) during the second half of an NFL football game at Ralph Wilson Stadium in Orchard Park, N.Y., Sunday, Dec. 23, 2007. The Giants won 38-21. (AP Photo/David Duprey)
New York Giants running back Ahmad Bradshaw (44) runs past Buffalo Bills cornerback Drayton Florence (29) during the first quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)
New York Giants free safety Antrel Rolle (26) tackles Buffalo Bills running back C.J. Spiller (28) by grabbing his helmet during the fourth quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Bill Kostroun)
New York Giants tight end Jake Ballard (85) evades Buffalo Bills cornerback Drayton Florence (29) during the third quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Bill Kostroun)
New York Giants wide receiver Mario Manningham (82) fends off Buffalo Bills cornerback Terrence McGee (24) during the third quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Bill Kostroun)
New York Giants' Hakeem Nicks (88) runs away from Buffalo Bills' Drayton Florence (29) during the second quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Kathy Willens)
Buffalo Bills quarterback Ryan Fitzpatrick, bottom, reacts after being sacked by New York Giants outside linebacker Mathias Kiwanuka (94) during the second quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)
New York Giants running back Ahmad Bradshaw (44) avoids a tackle by Buffalo Bills cornerback Terrence McGee (24) during the first quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Bill Kostroun)
Buffalo Bills' George Wilson, left, has a hold of New York Giants' Victor Cruz during the third quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Bill Kostroun)
New York Giants quarterback Eli Manning (10) prepares to take the snap during the second quarter of an NFL football game against the Buffalo Bills Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Bill Kostroun)
Buffalo Bills' Drayton Florence, left, attempts to tackle New York Giants' Jake Ballard during the third quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Bill Kostroun)
New York Giants running back Ahmad Bradshaw (44) runs away from Buffalo Bills defensive end Spencer Johnson (91) and Terrence McGee (24) during the fourth quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. The Giants won the game 27-24. (AP Photo/Kathy Willens)
New York Giants quarterback Eli Manning (10) throws during the second quarter of an NFL football game against the Buffalo Bills Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Kathy Willens)
New York Giants defensive end Jason Pierre-Paul (90) rushes against Buffalo Bills quarterback Ryan Fitzpatrick (14) during the second quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. Pierre-Paul was called for roughing the passer on the play. (AP Photo/Bill Kostroun)
New York Giants running back Ahmad Bradshaw (44) runs away from Buffalo Bills inside linebacker Nick Barnett (50) and Kelvin Sheppard (55) during the first quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Kathy Willens)
New York Giants running back Ahmad Bradshaw (44) dives past Buffalo Bills free safety Jairus Byrd (31) and Nick Barnett (50) for a touchdown during the third quarter of an NFL football game on Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Julio Cortez)
New York Giants running back Ahmad Bradshaw (44) is tackled by Buffalo Bills cornerback Terrence McGee (24) during the first quarter of an NFL football game Sunday, Oct. 16, 2011, in East Rutherford, N.J. (AP Photo/Bill Kostroun)
New York Giants wide receiver Rueben Randle (82) reacts after scoring a touchdown on a pass from quarterback Eli Manning as Buffalo Bills cornerback Stephon Gilmore, left, and strong safety Bacarri Rambo look on during the first half of an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New York Giants running back Rashad Jennings, right, looks at Buffalo Bills cornerback Ronald Darby, left, as he scores on a touchdown run during the second half of an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Gary Wiepert)
New York Giants wide receiver Dwayne Harris (17) dives at the goal line during a touchdown reception on a pass from quarterback Eli Manning, not pictured, during the first half of an NFL football game against the Buffalo Bills, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Gary Wiepert)
New York Giants wide receiver Rueben Randle, left, is hit by Buffalo Bills cornerback Stephon Gilmore while scoring on a touchdown reception on a pass from quarterback Eli Manning, not pictured, during the first half of an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Gary Wiepert)
New York Giants quarterback Eli Manning looks to pass against the Buffalo Bills during an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New York Giants running back Shane Vereen (34) breaks away from Buffalo Bills defensive tackle Kyle Williams (95) during the first half of an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New York Giants wide receiver Dwayne Harris, front, is tackled by Buffalo Bills defensive back Nickell Robey during the first half of an NFL football game, Sunday, Oct. 4, 2015, in Orchard Park, N.Y. (AP Photo/Bill Wippert)
New York Giants defensive tackle Dexter Lawrence (97) takes part in a week 2 regular season game against the Buffalo Bills at MetLife Stadium on Sunday September 15th, 2019 in East Rutherford, New Jersey
RB Saquon Barkley (26) at New York Giants vs Buffalo Bills at MetLife Stadium in East Rutherford, NJ
New York Giants running back Saquon Barkley (26) takes part in a week 2 regular season game against the Buffalo Bills at MetLife Stadium on Sunday September 15th, 2019 in East Rutherford, New Jersey
New York Giants defensive tackle Dexter Lawrence (97) takes part in a week 2 regular season game against the Buffalo Bills at MetLife Stadium on Sunday September 15th, 2019 in East Rutherford, New Jersey
New York Giants defensive tackle Dexter Lawrence (97) takes part in a week 2 regular season game against the Buffalo Bills at MetLife Stadium on Sunday September 15th, 2019 in East Rutherford, New Jersey
