- The Giants won their second straight game and evened their record at 2-2.
- The Giants improved to 8-1 in regular-season games vs. AFC East opponents under Tom Coughlin (plus two Super Bowl victories over New England). The only loss was to the Patriots in the 2007 season finale, a defeat the Giants avenged five weeks later in Super Bowl XLII.
- For the third week in a row, the Giants won the coin toss and deferred, giving Buffalo the ball at the start of the game so the Giants could get it to open the second half. The Bills went three-and-out on the game's first series, and the Giants kicked a field goal on their opening possession. After losing the first seven games in which they deferred, the Giants have won two in a row.
- The Bills rushed for just 55 yards, almost 100 yards less than their NFL-best average of 152.7 yards they owned entering the game. The 55 yards was the lowest total by a Giants opponent since Green Bay had the same total on Nov. 17, 2013.
- Buffalo's 14 first downs were the fewest for a Giants opponent since Tennessee had 12 on Dec. 7, 2014.
- The teams combined for 28 accepted penalties (11 by the Giants, 17 by Buffalo), the highest total in a Giants game since the Giants and Washington combined for 32 penalties (15 by the Giants) on Sept. 21, 2003. The previous high total in Coughlin's 12-year tenure with the team was 25 penalties vs. Chicago on Nov. 7, 2004 (14 for the Giants).
- The Giants and Bills combined for 220 penalty yards, the highest total in the Giants game since Oct. 6, 2013 vs Philadelphia (224, including 136 by the Giants).
- Buffalo's 17 penalties were the highest total by a Giants opponent in the Coughlin era and the most since Washington had 17 on Sept. 21, 2003.
- Josh Brown missed what was likely the longest extra point attempt of his career, and ended the Giants' lengthy streak in the process. This season, the ball is spotted at the 15-yard line for a PAT, making the kick 33 yards. But Geoff Schwartz's false start penalty forced Brown to attempt a 38-yard extra point, which hit the right upright and was no good.
It was the Giants' first missed PAT after 328 consecutive successes, which had been the NFL's second-longest streak (San Francisco was at 372 entering Week 4). The Giants had not missed an extra point since Oct. 21, 2007, when Lawrence Tynes was wide left on an extra point try vs. the 49ers.
- Brown had made 82 consecutive PATs in his three seasons with the Giants, including his first seven at the longer distance. Brown's personal streak was 114 consecutive extra point successes. His last miss had been on Nov. 28, 2010, when he played for St. Louis at Denver. In his 13-year career, Brown has missed only three of 397 extra point attempts.
- Because he wanted to get back the point he lost on the missed extra point, Coughlin elected to go for two when the Giants scored their final touchdown in the fourth quarter. Andre Williams ran for the two points, the Giants' first such conversion since Andre Brown scored on a similar run on Nov. 24, 2013.
Five standout performers in the Giants Sunday matchup vs. Bills
Coughlin's 166th career regular-season victory tied him with Pro Football Hall of Famer Paul Brown for 12th on the NFL's all-time list.
- Including his 12 postseason victories, Coughlin has 178 career triumphs. That ties him with former Oakland, Denver and Washington coach Mike Shanahan for 11th on the league's career list.
- Eli Manning completed 20 of 35 passes for 212 yards, three touchdowns and his first interception of the season. Manning was picked off by Stephon Gilmore late in the game. That ended his season-beginning streak of 142 passes without an interception. That was the second-longest streak to begin a season in Giants history. Fran Tarkenton was not intercepted in his first 163 passes in 1969.
- The 142 passes without an interception was the second-longest streak of Manning's career. He threw 176 passes without a pick last season before Seattle's Earl Thomas intercepted a throw that was tipped by Odell Beckham Jr. No. 2 on Manning's list had been a 124-pass streak without an interception from Sept. 11-Oct. 16, 2005.
- Manning's 212 passing yards at Buffalo increased his career total to 40,731. That moved him past Hall of Famer Joe Montana (40,551) and into 13th place on the NFL's career list. Former Giant Kerry Collins is 12th with 40,922.
- Manning's three touchdown passes increased his career total to 266, which is the 12th-highest total in history, seven less than Montana.
- The victory was Manning's 101st as a starting quarterback (93 regular season, eight postseason). That ties the franchise record set by Phil Simms (95 and six).
Rashad Jennings led the Giants in rushing with 38 yards on nine carries, and added two catches for 54 yards, including a 51-yarder for the team's final touchdown. The 51-yard reception was 24 yards longer than his previous long reception, a 24-yard on Nov. 23, 2014 vs. Dallas. It was the first career touchdown catch for Jennings, who has 134 career receptions.
- Odell Beckham Jr. caught five passes for 38 yards. The reigning Offensive Rookie of the Year has now played 16 career games, or a full regular-season schedule. He owns the records for catches and receiving yards in the first 16 games of a career, and is tied for fourth in touchdowns, and tied for second for most 100-yard games.
- MOST RECEPTIONS
Odell Beckham Jr. 115
Anquan Boldin 101
Terry Glenn 93
Eddie Royal 93
Reggie Bush 88
MOST RECEIVING YARDS
Odell Beckham Jr. 1,612
Bill Groman 1,593
Billy Howton 1,500
Charley Hennigan 1,426
Lance Alworth 1,399
MOST RECEIVING TDs
Randy Moss 17
Bob Hayes 16
Billy Howton 16
Odell Beckham Jr. 14
Lance Alworth 14
Bill Groman 14
John Jefferson 14
MOST 100-YARD GAMES
Bill Groman 9
Odell Beckham Jr. 8
Harlan Hill 8
Charley Hennigan 7
Julio Jones 6
Billy Howton 6
- Dwayne Harris started for the second time this season as the Giants opened the game in a three-wide receiver formation. He set a career high with his first five catches of the season and scored his first touchdown for the Giants, on a 21-yard pass from Manning.
Harris' previous best was four catches, which he had twice with Dallas: Nov. 22, 2012 vs. Washington and Dec. 10, 2012 vs. Pittsburgh. The touchdown was his first since Nov. 3, 2013, when he played for Dallas against Minnesota.
- Because Harris temporarily left the game with a rib injury, Shane Vereen returned a kickoff for the first time this season, for 25 yards. It was his first return since Dec. 29, 2013 for New England vs. Buffalo.
- Second-year linebacker Devon Kennard got his first career interception when he picked off Tyrod Taylor late in the first quarter. Two plays later, Manning threw to Harris for the 21-yard touchdown.
- The Giants' fullback is now among the team's sack leaders. Nikita Whitlock, the fullback who moonlights as a defensive tackle, dropped Taylor for a 14-yard loss and his first career sack on the Bills' final drive.
- Cullen Jenkins had the Giants' other sack, and leads the team with 2.0.
- Cornerback Prince Amukamara forced and recovered a fumble by Robert Woods in the fourth quarter.
- Defensive end Owa Odighizuwa and tight end Will Tye made their NFL debuts. Odighizuwa, the third-round draft choice who missed the first three games with a foot injury, had two tackles (one solo). Tye, who was signed off the practice squad on Saturday because two injured tight ends did not make the trip, dropped the only pass thrown to him.
- Defensive end Kerry Wynn led the Giants with eight tackles (seven solo).
- Left tackle Ereck Flowers temporarily left the game after the Giants' first offensive play because he aggravated the ankle injury that has bothered him for two weeks. He first suffered the injury vs. Atlanta on Sept. 20, and he did not play against Washington. Flowers was listed as questionable on the Giants' injury report on Friday. Justin Pugh once again moved from left guard to tackle, and John Jerry stepped in at guard. Flowers returned to the field with 4:33 left in the quarter for the Giants' third offensive possession and played the rest of the game.
The Giants' inactive players were wide receiver Victor Cruz (calf), defensive end Robert Ayers (hamstring), defensive tackle Markus Kuhn (knee), tight ends Daniel Fells (ankle) and Jerome Cunningham (knee), safety Cooper Taylor and linebacker Jasper Brinkley.
- Pugh joined season-long captains Manning, Jon Beason and Zak DeOssie for the coin toss.
- Buffalo's Dan Carpenter kicked a 51-yard field goal in the first quarter, the longest by a Giants opponent since St. Louis' Greg Zuerlein booted a 51-yarder last Dec. 21.