Three players are listed as out for Sunday night: tackle David Diehl (knee), cornerback Jayron Hosley (hamstring) and linebacker Kevin Rivers (hamstring).
Diehl will miss his second game in a row, increasing to six the number he has sat out in his 10-year career.
"My goal was to make it this week and I fell short of my goal," Diehl said. "I'm not there yet, but each and every day I'm working, coming in here, watching film, doing everything I can to help these guys. Sitting in the meetings, just doing everything like I normally would do. Once practice starts I go off and do all my rehab - I run, I try to do everything I can, I'm working to get back as fast as possible.
"My goal is next week, to be back for the Browns game. Like I said, each and every day it's gotten better. I'm feeling better. I'm doing more stuff each and every day. As much as it is that I want to get back out there, this is the first time I've ever had a knee injury or anything like it. I'm just thankful that it wasn't anything worse with how I got rolled up on. To not tear anything or need surgery, things could've been a lot worse."
This will be the second time in three years Diehl will miss the Giants' annual visit to Lincoln Financial Field.
"It's definitely tough missing this game," Diehl said. "Each and every year, this is one of the games…the rivalry, the tradition of playing each other, the dislike of one another. This is a game that you love playing, because it's going to be a fight for 60 minutes."