RB RASHAD JENNINGS The Giants needed a play late in Week 4, and Rashad Jennings gave it to them. Breaking tackles and swatting away would-be tacklers down the sideline, the veteran running back turned a short pass from Eli Manning into a 51-yard touchdown to put his team ahead by two touchdowns midway through the fourth quarter in Buffalo. The play sparked the Giants as they try to turn back-to-back wins into a bona fide winning streak. "He certainly did on Sunday," offensive coordinator Ben McAdoo said. "That was a big play in the game for us, and it was good to have him make it. It was a challenging play in the game, it's not like he just came up and made an ordinary play. He went above the X's and O's there and came through for us and provided a nice lift when we needed it."

TE LARRY DONNELL The Giants had to place veteran Daniel Fells on season-ending injured reserve this week, thus losing their best blocking tight end in the process. Now Larry Donnell, who has 15 receptions for 119 yards and a touchdown this year, is the leader of the tight end room. "Larry is the lead dog in there right now and he's got to stand up," McAdoo said. "He's got to lead those guys."

FB/DT NIKITA WHITLOCK A former college nose guard, fullback Nikita Whitlock is a throwback to the golden age of the NFL in his ability to play offense, defense and special teams. Coach Tom Coughlin said he has never had a player like Whitlock, who had a late sack against the Bills as a defensive tackle. "Pick your spots," Coughlin said. "You're talking about a guy, he's a tough hombre, but he's not very big."

DE KERRY WYNN For the third consecutive week, the Giants will be going up against one of the best rushing offenses in the NFL. This time, it's San Francisco, which is fifth in the league averaging 130.3 yards per game on the ground. For the Giants, no one has been better at stopping the run than defensive end Kerry Wynn. He is tied for third on the team with 16 solo tackles, including two for losses last week against Buffalo.   "I think Kerry Wynn has been one of our more consistent, dependable, physical, fast football players, and we've needed it obviously out there at defensive end," defensive coordinator Steve Spagnuolo said. "All these offensive systems, especially the one coming in here, are going to test your edges and the guys at the defensive end spot. I texted Kerry, it might have been two days ago, because I was watching practice tape. A lot of complimentary things to say because of how he had been playing, and certainly that way in the game."

LB JON BEASON With fellow linebackers Devon Kennard (hamstring) and Jonathan Casillas (calf) banged up, defensive captain Jon Beason will anchor the corps in the middle against a dual-threat quarterback in Colin Kaepernick and a top-10 rusher in Carlos Hyde, who had a career-high 168 yards in Week 1. "Well, with the exception of Devon and Uani ['Unga], we're a very veteran group," Beason said. "Guys have been getting nicked and a lot of us have our role now and everyone's played. We feel comfortable, so whoever goes in there, we represent the New York Giants defense. That's it."