CB PRINCE AMUKAMARA Without fellow corner Dominique Rodgers-Cromartie (concussion) last week against Washington, Amukamara stepped up and sparked the Giants with his first interception of the season. The play led to an early lead for the Giants as they picked up their first victory. Now Amukamara gets back Rodgers-Cromartie just in time to try to contain Bills quarterback Tyrod Taylor and the No. 3 scoring offense. "Just being smart and disciplined," Amukamara said of the key to the defense. "Anytime you have a quarterback that can run and pass, if you're supposed to be outside, be outside, if you're supposed to be inside, be inside, and just don't let them get the running game going. Once they get the running game going they can play action us, boot us, and then we'll have a big problem."

TE LARRY DONNELL Tight ends Daniel Fells (ankle) and Jerome Cunningham (knee) are battling injuries right now, leaving Larry Donnell as the only healthy one on the roster. Donnell has 10 catches for 81 yards through the first three games and a lone touchdown that came in Week 2. "We anticipated coming into the week that we could possibly be short on numbers," McAdoo said. "We just have to have everything backed up, that's all."

DE OWA ODIGHIZUWA The third-round pick out of UCLA is looking to become the last active member of the Giants' 2015 draft class to make his NFL debut. Odighizuwa missed the first three games with a foot injury but was upgraded this week to a full participant in practice. Defensive coordinator Steve Spagnuolo needs all the fresh legs he can get up front against Buffalo's No. 1 rushing attack. "He's got some juice," Spagnuolo said of Odighizuwa. "I think he's a strong edge player, I think he can play tight ends well. So I hope that helps us in the run defense and certainly when we get to a throwing down, some of those third downs, I'm hopeful, we're all hopeful, that he can bring something to the pass rush."

RB SHANE VEREEN With Victor Cruz (calf) again ruled out for Sunday, the Giants have just four active receivers who will likely suit up in Buffalo. That's where a player like Shane Vereen, who holds the Super Bowl record for most receptions by a running back, could come in handy. Offensive coordinator Ben McAdoo was asked this week if he is willing to use Vereen as a wide receiver. "Sure," he responded. "Why not?" Vereen is second only to Odell Beckham Jr. on the team to with 12 receptions this season.

WR DWAYNE HARRIS A week after getting Rueben Randle going (he had seven catches for 116 yards and a fourth-quarter touchdown that sealed the victory), the Giants will try to ramp up their production from the third wide receiver spot, which includes Dwayne Harris and rookie Geremy Davis. They have just one catch between them through three games. "You'd like to have everybody have plays distributed," coach Tom Coughlin said. "We got Rueben going, we need to get that spot going."