RB Andre WilliamsStarting running back Rashad Jennings, who is currently fourth in the NFL in rushing yards, was officially ruled out of Sunday's prime-time matchup in Philadelphia after injuring his knee in last week's win over Atlanta. That means rookie Andre Williams, like he did down the stretch in Week 5 after Jennings' injury, will shoulder the workload against the Eagles. Veteran and former 1,000-yard rusher Peyton Hillis will also be leaned on, as will Michael Cox, who was signed off the practice squad this week to bolster the position. >> RB ANDRE WILLIAMS TD AGAINST WASHINGTON

LB Jon BeasonThe starting middle linebacker has missed the last three games with a foot/toe injury but has progressed each week to the point of being listed as questionable for Sunday night. If he does return, he will be a big boost to a defense heading into back-to-back divisional games on the road. "He has practiced well," defensive coordinator Perry Fewell said. "Yeah, I have a greater confidence this week, just the way he looked and the way he has moved in practice, and the way he has conducted himself. We have given him a lot more reps than we did last week. Yeah, my confidence level is a lot better this week."

DE Jason Pierre-PaulStar players need to shine when it comes to rivalry games in prime-time, and Pierre-Paul fits that billing. Despite ranking in the middle of the pack with 10 sacks this season, the Giants have pressured opposing quarterbacks over their three-game winning streak and could be in line for a breakout game in the pass rush department. Pierre-Paul, who has 1.5 sacks this season (all against Arizona in Week 2), will lead the way, especially with fellow defensive end Robert Ayers' late appearance on the injury report this week. Ayers did not practice on Friday because of a neck issue and is questionable for Sunday. The defensive ends will also be critical on Sunday against Philadelphia's screen game, which is as good as it comes in the NFL.

C J.D. WaltonThe offense has grown more efficient with each game this season, and a large part of that is due to the consistency of the offensive line. The Giants have started the same five players up front in every game, and it all starts with the man in the middle. Walton will be key to setting the offense in a hostile road environment. "I like a scrappy guy in there," offensive coordinator Ben McAdoo said this week about the center position. "I like a tough guy in there. You usually like a guy you would take in a boxing ring in there, and I think he has those types of attributes. I think he has confidence and broad shoulders."

WR Odell Beckham Jr. The rookie first-round draft choice made his NFL debut last week one to remember, catching four passes for 44 yards, including the go-ahead touchdown from Eli Manning in the fourth-quarter comeback. The LSU product brings another dynamic threat to the offense while also potentially becoming a factor as a punt returner.  Look for him in both phases on Sunday in Philadelphia. >> ODELL BECKHAM'S FIRST NFL TOUCHDOWN