Leading the league in receiving yards over the previous two weeks, rookie wide receiver Odell Beckham Jr. warms up for the New York Giants' 1 p.m. kickoff against the San Francisco 49ers. >>VIEW GIANTS VS. 49ERS PREGAME PHOTOS

Looking to respond after last week's performance and end the four-game losing streak, the defense huddles before kickoff at MetLife Stadium. >>VIEW GIANTS VS. 49ERS PREGAME PHOTOS

On the opening possession of the game, cornerback Zack Bowman recovers a fumble by 49ers running back Frank Gore. >>WATCH CB ZACK BOWMAN FUMBLE RECOVERY

On the ensuing possession after the turnover, Eli Manning finds wide receiver Rueben Randle twice for gains of 20 and 18 yards to bring the Giants into 49ers territory. >>WATCH GIANTS VS. 49ERS HIGHLIGHTS

Manning hits Larry Donnell over the middle for a 19-yard touchdown, the tight end's sixth of the season. It ended the Giants' 20-game drought of not scoring a touchdown on their opening possession. >>WATCH TE LARRY DONNELL TD

RB Frank Gore breaks his longest run of the day for 17 yards to midfield.

The Giants bend but don't break, holding kicker Phil Dawson to a 31-yard field goal.

After Dawson tacked on another field goal, Manning throws his first of five interceptions on the day. >>WATCH ELI MANNING VS.49ERS 

The 49ers turn their first turnover into a 44-yard field goal by Dawson to take a 9-7 lead.

On third down, Manning connects with Donnell again for a 30-yard gain. >>WATCH TE LARRY DONNEL'S 30 YARD CATCH

Driving into San Francisco territory, Manning throws his second interception, this time into the hands of linebacker Michael Wilhoite.  >>WATCH ELI MANNING'S SECOND INTERCEPTION

San Francisco quarterback Colin Kaepernick hooks up with wide receiver Michael Crabtree for a 48-yard touchdown early in the second half to take a 16-7 lead. >>WATCH WR MICHAEL CRABTREE'S 48 YARD TD

The Giants respond with a scoring drive that results in a 43-yard Josh Brown field goal to cut it to a 16-10 deficit.

On the ensuing kickoff the Giants successfully convert an onside kick that linebacker Mark Herzlich recovers.  >>WATCH THE GIANTS RECOVER THE ONSIDE KICK

The Giants' momentum ends with another Manning interception on the ensuing possession. >>WATCH ELI MANNING'S THRID INTERCEPTION

After the defense forces a three-and-out, Manning hits Beckham three times on the next drive for gains of 19, 4, and 20 yards into 49ers territory. >>WATCH ODELL BECKHAM JR.'S 37 YARD CATCH

Cornerback Chris Culliver picks off Manning's pass attempt intended for Randle. >>WATCH ELI MANNING'S 4TH INTERCEPTION

Set up by a spectacular catch from Beckham, the Giants are unable to convert a first-and-goal from the four-yard line. After three incomplete passes, Manning's fourth-down attempt to Preston Parker is knocked in the air and intercepted by rookie linebacker Chris Borland. >>WATCH ELI MANNING'S 5TH INTERCEPTION

Manning addresses the media after the Giants' 16-10 loss to the 49ers.>>WATCH ELI MANNING'S POSTGAME INTERVIEW

Defensive co-captain Antrel Rolle discusses the Giants' fifth straight loss that dropped the team to 3-7 on the season.>>WATCH ANTREL ROLLE'S POSTGAME INTERVIEW