EAST RUTHERFORD, N.J. – Brian Daboll confirmed the inevitable this morning when he announced that Daniel Jones will not play Sunday night when the Giants visit the Buffalo Bills in Highmark Stadium.

The starting quarterback injured his neck in the fourth quarter of the team's loss last week in Miami.

"He won't make the game. He'll be out," Daboll said. "I think he's getting better but not good enough to play for this game."

Tyrod Taylor, a 13-year veteran, will start for the first time in his two seasons with the Giants. Rookie free agent Tommy DeVito will be elevated from the practice squad to serve as Taylor's backup.

"Tyrod's a pro," Daboll said. "He comes out every day and approaches it the right way in the backup situation, but he always approaches it as if he's the starter. He's had a good week, he's prepared well, but he does that every week."

Four other Giants will also be inactive with injuries, including three offensive linemen. Left tackle Andrew Thomas will miss his fifth consecutive game with a hamstring injury, rookie center John Michael Schmitz will be sidelined for a second straight week with a shoulder injury, and backup tackle Matt Peart will be inactive for the first time this season, also with a shoulder.

The starting configuration of the offensive line will be revealed when the offense first takes the field.

"We're kind of working through that," Dabll said. "We've been working through it during the week so again, we'll work through it today and come up with the five we're going to put out there."

Outside linebacker Azeez Ojulari, who missed the team's games last month in Arizona and San Francisco with a hamstring injury, is now sidelined with an injured ankle.

Saquon Barkley is one of seven players who are questionable. Barkley has missed the last three games with a sprained ankle.

"Each week he gets a little bit better," Daboll said. "What we do with all the players is we talk to the player, talk to the medical staff, make sure everybody's aligned with that, then we'll see how he does today. But he's making progress from where he was last week or the week before."

Jones will be sidelined due to injury for the first time since he missed the final six games of the 2021 season, also with a neck injury. This will be the 11th career game he will miss because of an injury – two with a sprained ankle in his 2019 rookie season, two in 2020 with hamstring and ankle injuries, and the six in 2021. The 2022 season was the only one of his five seasons in which he did not suffer an injury, though he was rested with most starters in the regular season finale in Philadelphia.

Neither Jones nor Daboll have revealed the specifics of the injury, though Jones said, "It's not the same injury" as his previous neck issue. He said Wednesday he thinks it is not a potential long-term injury.

"I'd just say that he's getting better so we'll see," Daboll said. "We'll take it day-by-day."

Taylor last started on Dec. 5, 2021, for the Houston Texans against the Indianapolis Colts. He is 26-25-1 as a regular starter in the NFL. Forty-two of those starts were for the Bills from 2015-17, when he 22-20.

"He's played a long time – this position," Daboll said. "Again, it takes all 11 people to do their job and to play well. Tyrod prepares himself, holds himself to a high standard and I know he'll do everything he can to go out there and put a good product on the field."

*Twelve players appear on the final injury report, five fewer than yesterday.

Tackle Evan Neal (ankle) and defensive lineman D.J. Davidson (knee) did not practice today after they were limited yesterday. They are listed as questionable along with Barkley, tight end Darren Waller (groin), running back Gary Brightwell (ankle), offensive lineman Shane Lemieux (groin), and linebacker Micah McFadden (ankle).

*The players removed from the injury report were wide receiver Wan'Dale Robinson (knee), who was limited in practice, and defensive backs Deonte Banks (ankle) and Cor'Dale Flott (ankle), offensive lineman Marcus McKethan (knee) and punter Jamie Gillan (illness), who were all full participants.

*Offensive lineman Justin Pugh, who was signed to the practice squad last week, could make his debut in his second tour of duty with the Giants.

"He's out practicing, so there's definitely a possibility," Daboll said. "He's been here a short amount of time; he's smart. We're working through some (offensive line) combinations right now."

*Daboll and Taylor are among the several Giants who spent time with the Bills.

Daboll grew up in and attended St. Francis High School in Western New York and was Buffalo's offensive coordinator from 2018-21.

Giants general manager Joe Schoen was the Bills assistant G.M. from 2017-21.

The players besides Taylor who wore a Buffalo uniform are running back Matt Breida, wide receiver Isaiah Hodgins, defensive back Nick McCloud, outside linebacker Boogie Basham, wide receiver Cole Beasley (practice squad) and tight end Tommy Sweeney (reserve/non-football injury list).

Assistant coaches John Egorugwu, Bobby Johnson and Shea Tierney all worked for the Bills.