EAST RUTHERFORD, N.J. – Notes and statistics from the Giants' 40-24 loss to the Indianapolis Colts in MetLife Stadium:

• The Giants lost their third game in a row to fall to 3-5. It is their second-worst midseason record in Tom Coughlin's 11 years as head coach. They were 2-6 in 2013, when they finished 7-9.

• The Giants trailed in the fourth quarter, 40-10, before Eli Manning threw a pair of late touchdown passes to Larry Donnell and Corey Washington.

• The Colts' 40 points were the most scored by a Giants opponent since Denver's total in a 41-23 victory in MetLife on Sept. 15, 2013.

• The Giants gained 448 yards, their second-highest figure of the season; they totaled 449 yards in a victory at Washington on Sept. 25.

• Indianapolis gained 443 yards, the fifth time in eight games a Giants opponent totaled more than 400 yards.

• The Giants' 349 net passing yards was their highest total since they threw for 353 yards in the loss to Denver last season.

• The Colts' 345 passing yards was the highest total for a Giants opponent since New Orleans threw for the same figure on Dec. 9, 2012.

• Each team had 22 first downs.

Eli Manning threw 52 passes (completing 27 for 359 yards, two touchdowns and no interceptions). The Giants fell to 1-20 in their history in regular-season games in which they throw at least 50 passes, including 1-18 when one quarterback does it. Manning is 1-4; the victory was on Sept. 16, 2012, when he threw 51 passes in a victory over Tampa Bay. The Giants won the 2011 NFC Championship Game in San Francisco when Manning threw 58 passes.

• The 52 passes tied for the second-highest total in Manning's regular-season career. He had 53 attempts at Seattle on Nov. 27, 2005 and against Washington on Dec. 16, 2007 and 52 vs. Philadelphia on Oct. 6, 2013.

• The 300-yard game was Manning's second of the season and 30th of his career. The Giants are 14-16 in those games. The 359 yards marked Manning's highest total since he threw for 362 yards vs. Denver on Sept. 15, 2013.

• Manning has not thrown an interception in his last 145 passes, the longest streak of his career. The previous long was 124 throws without a pick from Sept. 11-Oct. 16, 2005, a streak ended on an interception by Dallas' Anthony Henry. This is the fourth time in his career Manning has thrown at least 100 passes without an interception.

Manning started his 159th regular-season game, tying the franchise record for quarterbacks set by Phil Simms from 1979-93.

• Coughlin has been the head coach for each of Manning's 159 starts. They broke a tie with Pittsburgh Hall of Famers Terry Bradshaw and Chuck Noll and moved into third place on the all-time list of quarterback/head coach duos, behind New England's Tom Brady and Bill Belichick (200) and Miami's Dan Marino and Don Shula (184).

• Manning's 18-yard run in the fourth quarter tied his career long. He had an 18-yarder vs. Miami in London on Oct. 28, 2007.

• Indianapolis quarterback Andrew Luck completed 25 of 46 passes for 354 yards, four touchdowns and no interceptions. He is the first opponent to throw four touchdown passes against the Giants since Cincinnati's Andy Dalton on Nov. 11, 2012 and the first to do it in MetLife since Green Bay's Aaron Rodgers on Dec. 4, 2011.

• Giants rookie receiver Odell Beckham Jr. had career-high totals of eight catches for 156 yards. The eight receptions matched Rueben Randle's total at Washington for the Giants' season high. Beckham's 156 yards were the most by a Giant since Victor Cruz had 164 at Kansas City on Sept. 29, 2013. His 59-yard catch was the second-longest by a Giant this season; Cruz had a 61-yarder vs. Houston.

• Donnell had four catches for 25 yards, including his team-leading fifth touchdown.

Washington, a rookie free agent, had his first four NFL receptions, for 48 yards, and scored his first professional touchdown.

• Michael Cox led the Giants with 27 yards on two carries – 17 of them on the game's final play.

• Rookie Andre Williams, who started his third game in place of the injured Rashad Jennings, gained just 22 yards on 12 carries, but scored the Giants' first touchdown on a one-yard run – which was set up by his 24-yard reception on the previous play.

• Coughlin is 0-7 vs. the Colts. The only other team he has never beaten is San Diego (0-3). Manning is 0-3 vs. the Colts.

• The Giants' already-depleted cornerbacks corps suffered a significant loss when Prince Amukamara tore his biceps in the second quarter, an injury that is expected to sideline him for the remainder of the season. The Giants compensated with a variety of personnel groups. They paired cornerbacks Zack Bowman - who was playing the majority of the snaps for banged-up left cornerback Dominique Rodgers-Cromartie - and DRC, who moved over to the right side. Nickel back Jayron Hosley played numerous snaps. The Giants also used a three-safety alignment with Antrel Rolle, Quintin Demps and Stevie Brown.

• Fullback Henry Hynoski's second rushing attempt of the season gained two yards and picked up a first down in the second quarter.

• Josh Brown attempted – and made – his first field goal since Oct. 5 against Atlanta, a 38-yarder in the second quarter. Moments later, he made a solo tackle of Griff Whalen on the kickoff after a 30-yard return.

• Defensive tackle Mike Patterson started for the first time this season in place of Cullen Jenkins, who was inactive with a calf injury. It was Patterson's first start since Oct. 6, 2013 vs. Philadelphia.

• Hosley started for the first time this season as a nickel back. It was his first start since Dec, 1, 2013 at Washington.

The Giants' inactive players were running back Rashad Jennings (knee), defensive tackle Cullen Jenkins (calf), offensive linemen Charles Brown, James Brewer and Brandon Mosley, defensive end Kerry Wynn and cornerback Mike Harris.

Jenkins' absence ended his streak of consecutive regular-season games played at 55. He had last missed a game on Jan. 2, 2011, the last game of his final season in Green Bay.

• Rookie left guard Weston Richburg was carted off the field in the fourth quarter with an ankle injury.

• The Giants did not have a takeaway for the third time this season (also at Detroit and vs. Arizona). They have lost their last 13 regular-season games in which they did not force a turnover.

• The Giants' six-game post-bye winning streak ended. They are 10-16 overall following a regular-season bye.

• The Giants are 22-35-1 on Monday night, including 8-9 at home. They lost both of their Monday night games this season, including their opener in Detroit. This was just the third Monday night home game in Coughlin's tenure. The Giants defeated St. Louis in 2011 and Minnesota last season.

• This was just the second Monday night meeting between the Giants and Colts and it occurred almost 24 years to the day after the first one. On Nov. 5, 1990, the Giants defeated the Colts in Indianapolis, 24-7.

• Jacquian Williams led the Giants with 17 tackles (13 solo). Robert Ayers had the Giants' only sack of Luck, a nine-yarder.