Notes and statistics from the Giants' 38-17 loss to the Seattle Seahawks in CenturyLink Field:

• The Giants lost their fourth consecutive game and fell to 3-6. They host the San Francisco 49ers next week.

• The Seahawks gained 510 yards, the highest total allowed by the Giants since Baltimore had 533 yards on Dec. 23, 2012. It is the fourth-highest yardage total given up by the Giants in Tom Coughlin's 11 years as head coach.

• Seattle rushed for 350 yards, the third-highest total ever allowed by the Giants. The Boston Redskins ran for 420 yards on Oct. 8, 1933 and the Bills rushed for 366 yards in Buffalo on Nov. 26, 1978. The Seahawks were the first team with at least at least 350 rushing yards and five touchdowns since the Bills did in in that 1978 game vs. the Giants.

• The Seahawks' 27 first downs were the most for a Giants opponent since Philadelphia had 28 on Oct. 6, 2013.

• Seattle punted just once, the first Giants opponent with a single punt since San Diego on Dec. 8, 2013.

• The Giants rushed for 54 yards, their second-lowest total of the season. They ran for 53 yards in their season-opening loss in Detroit.

• The Giants led at halftime, 17-14. This was the first game they lost after holding a halftime lead since Dec. 3, 2012 at Washington, where a 13-10 advantage became a 17-16 defeat. The Giants had won their previous nine games in which they owned a halftime lead, including two this season (Houston and Washington).

• The Giants were shut out in the second half for the second time this season (also in their 27-0 loss in Philadelphia on Oct. 12). Prior to that, the Seahawks were the last team to keep the Giants scoreless in a second half, in their 23-0 victory last Dec. 15.

• This was the first time the Giants scored at least 17 points in a first half before going scoreless in the second half since Nov. 26, 2006 at Tennessee, where they led, 21-0, but lost, 24-21.

• The Giants forced three turnovers and had two giveaways. It was the second time this season they lost despite having the turnover differential in their favor. It also happened in Philadelphia on Oct. 12 (when they had a 2-1 takeaway advantage).

The Giants have won just four of their last 13 road games.

• The Giants are 7-20 in regular-season games against defending Super Bowl champions (plus 3-0 in the postseason). Their last regular-season victory over a defending champion was on Dec. 13, 1998, when they beat the 13-0 Denver Broncos, 20-16.

• The Giants are 28-30 in games following a Monday night game, including 10-9 since 2000.

• The Seahawks scored a touchdown on their first offensive series on Marshawn Lynch's one-yard run. Seattle was the third opponent to score a first-possession touchdown vs. the Giants this season, joining Detroit and Arizona from the season's first two games. The Giants are 0-3 this year and 18-20 under Coughlin when the opposing team scores a first-possession touchdown.

• Before Lynch's touchdown, the Giants took the opening kickoff but punted after running four plays. It was their 20th consecutive game without scoring a first-possession touchdown, the NFL's longest active streak. The Giants have not scored a point on their first offensive series this season. They last scored first-possession points at Detroit last Dec. 22, when Josh Brown kicked a 41-yard field goal.

• Eli Manning completed 29 of 44 passes for 283 yards, one touchdown and one interception.

• A third-quarter Manning pass was tipped in the end zone by Odell Beckham Jr. and intercepted by safety Earl Thomas. That ended Manning's career-long streaks of 176 passes and 4½ games without throwing an interception. That far eclipsed Manning's previous best of 124 passes without an interception, set in 2005.

• Manning started his 160th career game, a record for a Giants quarterback. He had been tied with Phil Simms for the franchise record at 159.

• Beckham caught seven passes for 108 yards, his second consecutive 100-yard game. He is the second Giants receiver with back-to-back 100-yard performances this season. Victor Cruz had 107 and 108 yards vs. Houston and at Washington on Sept. 21 and 25.

• Preston Parker also had seven receptions, which was his career high. Parker's previous best was six catches for Tampa Bay at Minnesota on Sept. 18, 2011.

Parker caught the Giants' only aerial touchdown, a six-yarder in the first quarter. It was his first touchdown as a Giant and first since Nov. 13, 2011, when he caught a nine-yard scoring pass from Josh Freeman while playing for Tampa Bay against Houston.*Lynch rushed for 140 yards and four touchdowns. The 140 yards was the second-highest total by a Giants opponent this season; Philadelphia's LeSean McCoy ran for 149 yards on Oct. 12.

• Lynch scored on touchdown runs of one, two, three and 16 yards. He is the first Giants opponent to rush for four touchdowns in a game since Dec. 21, 2008, when Carolina's DeAngelo Williams scored on runs of 13, five, one and 30 yards in a 34-28 Giants overtime victory.

• Quarterback Russell Wilson ran for 107 yards (in addition to passing for 172 yards on just 10 completions). Lynch and Russell are the first pair of Giants opponents to rush for at least 100 yards in the same game since Dec. 23, 2013, when Baltimore's Bernard Pierce ran for 123 yards and Ray Rice added 107.

• The last time one of two 100-yard rushers against the Giants was a quarterback was Oct. 28, 2002 when Philadelphia's Donovan McNabb ran for 107 yards and running back Duce Staley led the team with 126.

• Wilson is the third quarterback to rush for more than 100 yards against the Giants. McNabb was the first and Michael Vick was the second on Dec. 19, 2010 with 130 yards, the most ever by a quarterback against the Giants.

• With Lynch and Wilson, the Seahawks were the first team in NFL history to have a running back rush for at least four touchdowns and a quarterback with more than 100 rushing yards in the same game.

• Cornerback Zack Bowman and safety Quintin Demps each intercepted Wilson passes. It was Demps' third pick of the season, tying him with Antrel Rolle and Prince Amukamara for the team lead, and Bowman's second.

• Bowman started for the first time this season, in place of Amukamara at right cornerback. Amukamara was placed on injured reserve last week after suffering a torn biceps against Indianapolis.

• Demps started his sixth consecutive game at free safety, but split time with Stevie Brown, who he replaced in the starting lineup.

• Robert Ayers and Johnathan Hankins each sacked Wilson. Ayers now leads the Giants with 4.0 sacks, and Hankins is tied with Jason Pierre-Paul for second with 3.5. Ayers is a defensive end, but he took numerous snaps at tackle vs. the Seahawks.

Jameel McClain led the Giants with 12 tackles (five solo) and a forced fumble (that was recovered by Rolle).

• Defensive tackle Cullen Jenkins returned to action after missing one game with a calf injury and was in on two tackles and had a quarterback hit. Mike Patterson again started in his place.

• Cornerback Chykie Brown, acquired off waivers last week, made his Giants debut in some sub defenses and on special teams.

• The Seahawks scored a second-quarter touchdown on the first 15-play drive against the Giants this season. It was the first 15-play series by a Giants opponent since Dec. 8, 2013, when San Diego held the ball for that many plays. That series ended with a field goal. Seattle's drive was the first of at least 15 plays against the Giants to end with seven points since Nov. 20, 2011, when Philadelphia had an 18-play touchdown drive in MetLife Stadium.

• Seattle coach Pete Carroll won a replay with 10:16 remaining in the first half. Manning lofted a pass to the left sideline that Rueben Randle caught for a 21-yard gain. Carroll challenged the ruling, claiming Randle was out of bounds. After review referee Peter Morelli determined Randle's foot did hit the sideline and overturned the ruling on the field, making the pass incomplete. Giants opponents are 3-1 this season and 32-36 in Coughlin's 11 years as head coach on replay challenges.

• The Giants suffered several injuries. Running back Peyton Hillis left the game in the first quarter with a concussion. His absence left the Giants with only two running backs, rookie starter Andre Williams and Michael Cox – until Cox suffered a lower leg fracture late in the game. Rookie safety Nat Berhe injured his ankle and tight end Daniel Fells had a burner.

• Mathias Kiwanuka joined captains Manning, Rolle and Zak DeOssie for the pregame coin toss.

• The Giants have lost their last three games against the Seahawks, but lead the all-time series, 9-8. They are 3-5 in Seattle.

• The Giants' inactive players were running back Rashad Jennings (knee), cornerback Mike Harris, offensive linemen Adam Snyder, Brandon Mosley and James Brewer, defensive tackle Jay Bromley and defensive end Kerry Wynn.