Week 2 was unkind to the 49ers on the injury front, as it was to the Giants, who saw Saquon Barkley suffer a season-ending knee injury and Sterling Shepard leave with turf toe. Shepard was placed on injured reserve, meaning he is eligible to be reinstated to the roster after missing three games.
San Francisco lost defensive linemen Nick Bosa, the 2019 NFL Defensive Rookie of the Year, and Solomon Thomas for the year due to knee injuries. Starting quarterback Jimmy Garoppolo also suffered an ankle injury and was ruled out for Sunday. Nick Mullens will start in his place.
Mullens has started eight previous games in his career, including a 2018 meeting with the Giants. He threw one touchdown and two interceptions before the Giants won on a last-minute touchdown pass from Eli Manning to Sterling Shepard.
Below is a look at the inactive list:
New York Giants
CB Brandon Williams
DB Adrian Colbert
LB TJ Brunson
OT Jackson Barton
TE Eric Tomlinson
DL RJ McIntosh
San Francisco 49ers
QB Jimmy Garoppolo
CB Ahkello Witherspoon
RB Raheem Mostert
DE Dee Ford
OLB Dre Greenlaw
OT Tom Compton
TE George Kittle
View photos of the Giants' active roster as it currently stands.
![HUDDLE](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/spuxvwy900ndrzdvufvv.jpg)
![OT Jackson Barton](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/bdwjnjfb83amt9mjrk7t.jpg)
OT Jackson Barton
![WR C.J. Board](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/ekhpgajuz5yvdlpb0k57.jpg)
WR C.J. Board
![CB James Bradberry](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/anhuh00z824iuwpfkxf4.jpg)
CB James Bradberry
![LB Cam Brown](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/iva30iuba9xqoxrj84cj.jpg)
LB Cam Brown
![LB TJ Brunson](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/nhl2su7gi9w9nljnbkxg.jpg)
LB TJ Brunson
![DB Adrian Colbert](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/d1euw8dwvd4rr63pplbx.jpg)
DB Adrian Colbert
![LB Carter Coughlin](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/o7ey2wl3qwu1dioq8wv2.jpg)
LB Carter Coughlin
![LB Tae Crowder](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/va2bp5o3llfedwjyyfpj.jpg)
LB Tae Crowder
![P Riley Dixon](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/f9vhupjk2allmdqgqwki.jpg)
P Riley Dixon
![LB Devante Downs
(Kevin Terrell via AP)](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/o3shgaqmdg6yfxn9heyw.jpg)
LB Devante Downs
(Kevin Terrell via AP)
![DB Nate Ebner](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/vbd8c11i7wlifcbpxiju.jpg)
DB Nate Ebner
![TE Evan Engram](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/iw3q0wmn03omrxzyxd8i.jpg)
TE Evan Engram
![LB Kyler Fackrell](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/uiiilkxein5nllo9ik3b.jpg)
LB Kyler Fackrell
![OT Cameron Fleming](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/bao1imefy6k9p1h2hpfb.jpg)
OT Cameron Fleming
![RB Wayne Gallman](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/eucmdhrwmbtod5xelksn.jpg)
RB Wayne Gallman
![K Graham Gano](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/kvlfefzpmpbsdbgp3zbj.jpg)
K Graham Gano
![G Nick Gates](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/gty0cj6khpa3v3grt28a.jpg)
G Nick Gates
![DB Madre Harper](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/cvrswltax0xrdfpjuwee.jpg)
DB Madre Harper
![G Will Hernandez](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/x3yypkkzg9ptbw3vygar.jpg)
G Will Hernandez
![DL B.J. Hill
(AP Photo/Bill Kostroun)](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/qujkakdkublsqanf9pdo.jpg)
DL B.J. Hill
(AP Photo/Bill Kostroun)
![DB Darnay Holmes](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/np6wiuy5fot4kxdopked.jpg)
DB Darnay Holmes
![DT Austin Johnson](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/jfhh05lp7sn5abnc6lh3.jpg)
DT Austin Johnson
![QB Daniel Jones](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/yexmogu4l3kfnut7fnih.jpg)
QB Daniel Jones
![LS Casey Kreiter](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/ujot1eggfioucrc5mv98.jpg)
LS Casey Kreiter
![DE Niko Lalos](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/rsxu7apoecdyp3bhbjgi.jpg)
DE Niko Lalos
![DL Dexter Lawrence](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/wbi58cqqxcx7dxnnhurf.jpg)
DL Dexter Lawrence
![G Shane Lemieux](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/cvrdoa1qyjk8qmijgyvn.jpg)
G Shane Lemieux
![RB Dion Lewis](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/snlqent9fi76my4jastp.jpg)
RB Dion Lewis
![CB Julian Love](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/lfawcjnpcmxxxmjhbcfp.jpg)
CB Julian Love
![WR Austin Mack](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/j18jou5hmcgzpu1bnihg.jpg)
WR Austin Mack
![LB Blake Martinez](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/bkragexcp8vqg9jdlizf.jpg)
LB Blake Martinez
![LB David Mayo](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/yhwqbngeahcu01hmi0gf.jpg)
LB David Mayo
![QB Colt McCoy](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/zthofywusvlywdnxufqg.jpg)
QB Colt McCoy
![DL R.J. McIntosh
(Scott Boehm via AP)](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/ydbut3ojkdn3vxvvaytp.jpg)
DL R.J. McIntosh
(Scott Boehm via AP)
![DB Xavier McKinney](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/qujqicznhsxjbb2lvgij.jpg)
DB Xavier McKinney
![RB Alfred Morris](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/xhqfxztltzft0ioqkqp4.jpg)
RB Alfred Morris
![OL Kyle Murphy](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/mqnujhgumvdhh1ekq3tq.jpg)
OL Kyle Murphy
![OT Matt Peart](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/uw7o4wcuxiwzxs664wtt.jpg)
OT Matt Peart
![S Jabrill Peppers](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/l1iylenvrgaemekjm9lk.jpg)
S Jabrill Peppers
![WR Dante Pettis](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/hlu0c7cl8h9dhglnvqnv.jpg)
WR Dante Pettis
![C Spencer Pulley](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/yyoimuo7dgkjemucsjcv.jpg)
C Spencer Pulley
![DB Logan Ryan](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/y4awksxwormlpqwlweud.jpg)
DB Logan Ryan
![DE Jabaal Sheard](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/m36pkgzcqetcf1yjq5ga.jpg)
DE Jabaal Sheard
![WR Sterling Shepard](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/m4zbgff1yjvdtegnmrwn.jpg)
WR Sterling Shepard
![WR Darius Slayton
(AP Photo/Michael Perez)](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/hfndsn6gfz6dxzdrwwir.jpg)
WR Darius Slayton
(AP Photo/Michael Perez)
![TE Kaden Smith](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/dcktoyek3yiwprw8gf1e.jpg)
TE Kaden Smith
![WR Golden Tate III](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/fy4kdskartfedq1f9808.jpg)
WR Golden Tate III
![OT Andrew Thomas](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/fmfqkaxdisimmbgj4vpd.jpg)
OT Andrew Thomas
![TE Levine Toilolo](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/osblo9cewr4uparw5v3h.jpg)
TE Levine Toilolo
![DL Dalvin Tomlinson](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/bgc1qhukysqynjisfbbv.jpg)
DL Dalvin Tomlinson
![DL Leonard Williams](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/hrlemaunhicnst1khykp.jpg)
DL Leonard Williams
![CB Isaac Yiadom](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/synrdpukr2wnvjucjr4g.jpg)
CB Isaac Yiadom
![G Kevin Zeitler](https://static.clubs.nfl.com/image/private/t_new_photo_album/t_lazy/f_auto/giants/lbqlfqbjtc0w629u4byq.jpg)
G Kevin Zeitler
![24_GiantsTV_GenericPromo_1920x1080](https://static.clubs.nfl.com/image/upload/t_editorial_landscape_mobile/t_lazy/f_auto/giants/qw055affpi9wmkfapsuq.jpg)
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