Week 2 was unkind to the 49ers on the injury front, as it was to the Giants, who saw Saquon Barkley suffer a season-ending knee injury and Sterling Shepard leave with turf toe. Shepard was placed on injured reserve, meaning he is eligible to be reinstated to the roster after missing three games.
San Francisco lost defensive linemen Nick Bosa, the 2019 NFL Defensive Rookie of the Year, and Solomon Thomas for the year due to knee injuries. Starting quarterback Jimmy Garoppolo also suffered an ankle injury and was ruled out for Sunday. Nick Mullens will start in his place.
Mullens has started eight previous games in his career, including a 2018 meeting with the Giants. He threw one touchdown and two interceptions before the Giants won on a last-minute touchdown pass from Eli Manning to Sterling Shepard.
Below is a look at the full injury report:
New York Giants
Doubtful: DB Adrian Colbert (quad)
Questionable: DB Brandon Williams (groin)
San Francisco 49ers
Out: RB Tevin Coleman (knee), DE Dee Ford (back), QB Jimmy Garoppolo (ankle), LB Dre Greenlaw (quad), TE George Kittle (knee), RB Raheem Mostert (knee)
Questionable: CB Ahkello Witherspoon (hamstring)
View photos of the Giants' active roster as it currently stands.
OT Jackson Barton
WR C.J. Board
CB James Bradberry
LB Cam Brown
LB TJ Brunson
DB Adrian Colbert
LB Carter Coughlin
LB Tae Crowder
P Riley Dixon
LB Devante Downs
(Kevin Terrell via AP)
DB Nate Ebner
TE Evan Engram
LB Kyler Fackrell
OT Cameron Fleming
RB Wayne Gallman
K Graham Gano
G Nick Gates
DB Madre Harper
G Will Hernandez
DL B.J. Hill
(AP Photo/Bill Kostroun)
DB Darnay Holmes
DT Austin Johnson
QB Daniel Jones
LS Casey Kreiter
DE Niko Lalos
DL Dexter Lawrence
G Shane Lemieux
RB Dion Lewis
CB Julian Love
WR Austin Mack
LB Blake Martinez
LB David Mayo
QB Colt McCoy
DL R.J. McIntosh
(Scott Boehm via AP)
DB Xavier McKinney
RB Alfred Morris
OL Kyle Murphy
OT Matt Peart
S Jabrill Peppers
WR Dante Pettis
C Spencer Pulley
DB Logan Ryan
DE Jabaal Sheard
WR Sterling Shepard
WR Darius Slayton
(AP Photo/Michael Perez)
TE Kaden Smith
WR Golden Tate III
OT Andrew Thomas
TE Levine Toilolo
DL Dalvin Tomlinson
DL Leonard Williams
CB Isaac Yiadom
G Kevin Zeitler
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