**QUARTERBACK: Eli Manning vs. Drew Brees
**Eli Manning and the Giants bring the fourth-best passing offense (281.4 yards/game) down to New Orleans, home of the Saints' prolific offense led by Drew Brees. Brees leads the NFL in attempts, completions and yardage, and is on pace to break Dan Marino's single-season yardage record of 5,084 in 1984. Brees has completed 299 of 422 passes (70.9 percent) for 3,326 yards, 23 touchdowns, 11 interceptions and a passer rating of 101.3. Meanwhile, Manning returns to his hometown just shy of 3,000 yards on the season with 18 touchdowns and nine interceptions.
"When I first got to town you learn very quickly that this is the city that the Mannings are from," Brees said. "Archie, obviously having played here and lived here ever since and being very involved with the community and Eli and Peyton both, with everything that they've accomplished. People definitely take a lot of pride in saying those guys are from New Orleans."
"It is a special place," Manning said. "I grew up going to games there so it is always a special trip. It will be my second trip down there. I'm really treating it like every other away game. I'm not seeing any family or friends or any sight-seeing. I'm going in there as a business trip and know that we have a big game. I want to go out there and make sure that our offense and our team is playing our best."
SAFETY: Antrel Rolle vs. Roman Harper
Both two-time Pro Bowlers, Antrel Rolle and Roman Harper lead their teams in tackles. Rolle has 62 with one interception while Harper has notched 79 with zero interceptions. Harper does, however, lead all NFL safeties (and the Saints) with 6.5 sacks.
**WIDE RECEIVER: Hakeem Nicks vs. Marques Colston
**Since missing two games with a broken collarbone sustained in the season opener, Marques Colston leads the Saints' receivers with 42 catches, 589 yards and three touchdowns. Hakeem Nicks has one more catch with 685 yards and four scores, averaging 15.9 yards per catch. Nicks also edges out Colston in catches of 20 yards or more with nine, compared to Colston's eight.