Brian Daboll confirmed the inevitable Friday morning when he announced that Daniel Jones would not play Sunday night when the New York Giants visit the Buffalo Bills in Highmark Stadium.
The starting quarterback injured his neck in the fourth quarter of the team's loss last week in Miami.
"He won't make the game. He'll be out," Daboll said. "I think he's getting better but not good enough to play for this game."
Tyrod Taylor, a 13-year veteran, will start for the first time in his two seasons with the Giants. Rookie free agent Tommy DeVito was elevated from the practice squad to serve as Taylor's backup.
"Tyrod's a pro," Daboll said. "He comes out every day and approaches it the right way in the backup situation, but he always approaches it as if he's the starter. He's had a good week, he's prepared well, but he does that every week."
Three offensive linemen were also inactive with injuries. Left tackle Andrew Thomas will miss his fifth consecutive game with a hamstring injury, rookie center John Michael Schmitz will be sidelined for a second straight week with a shoulder injury, and backup tackle Matt Peart will be inactive for the first time this season, also with a shoulder.
Outside linebacker Azeez Ojulari, who missed the team's games last month in Arizona and San Francisco with a hamstring injury, is now sidelined with an injured ankle.
On Saturday, the Giants placed Ojulari on injured reserve among a series of roster moves. The Giants also activated veteran offensive lineman Justin Pugh from the practice squad for the first time since the former first-round draft pick returned to the Giants. Jalen Mayfield, another offensive lineman, was signed to the active roster from the practice squad.
Running back Saquon Barkley, meanwhile, was one of seven players who were listed as questionable heading into Sunday night. Barkley missed the last three games with a sprained ankle but will return this week.
Tackle Evan Neal (ankle) and defensive lineman D.J. Davidson (knee) did not practice Friday after they were limited Thursday. They were listed as questionable along with Barkley, tight end Darren Waller (groin), running back Gary Brightwell (ankle), offensive lineman Shane Lemieux (groin), and linebacker Micah McFadden (ankle).
Below is the inactive list for Giants vs. Bills:
- QB Daniel Jones
- S Bobby McCain
- S Gervarrius Owens
- C John Michael Schmitz
- T Matt Peart
- T Andrew Thomas
- DL D.J. Davidson
- S Damar Hamlin
- CB Dane Jackson
- OLB A.J. Klein
- T Germain Ifedi
- G Alec Anderson
- TE Dalton Kincaid
View photos of the Giants arriving for their Week 6 matchup with the Buffalo Bills.