The defeat snapped the Giants' three-game winning streak and left them at 6-3, one game ahead of the Dallas Cowboys in the NFC East.
*The Giants finished 2-2 vs. the NFC West, beating St. Louis and Arizona but losing to Seattle and San Francisco.
*The Giants gained more yards (395-305), had more first downs (21-16) and owned the ball significantly longer (34:37-25:23) than San Francisco.
*The time of possession of 34:37 was the Giants' highest since they owned the ball for 37:51 in a loss to Dallas on Nov. 14, 2010.
*The Giants punted just twice, their lowest total since they punted once at Seattle on Nov. 7, 2010.
*The Giants led after three quarters, 13-12. They had won their previous four games in which they held a lead entering the final quarter, last losing vs. Philadelphia on Dec. 19, 2010. The Giants had won their nine previous road games in which they led after three quarters dating back to a victory at Tampa Bay on Sept. 27, 2009.
*The Giants held San Francisco to 77 rushing yards – including 27 yards on scrambles by quarterback Alex Smith - about 100 yards less than the 49ers' averaged in their previous five games (178.4). Frank Gore, who had rushed for more than 100 yards in each of those five games, gained zero yards on six carries before leaving with an ankle injury.
*The Giants did not score a first-half touchdown for the second consecutive game, the first time that's happened since they went three games in a row from Nov. 14-28, 2010 vs. Dallas, Philadelphia and Jacksonville.
*The Giants did not allow a first-half touchdown for the second game in a row, the first time they accomplished that since Oct. 3 and 10, 2010 against Chicago and Houston.
*The Giants' last and first drives of the game included 16 and 14 plays, respectively, their two longest series of the year in terms of the number of snaps. The last series, which ended with Justin Smith batting down Eli Manning's fourth-down pass, was the most plays in a Giants' possession since their 19-play drive to close out a 41-7 victory in Seattle on Nov. 7, 2010. The game-opening field goal drive consumed 8:33 and was the Giants' longest drive in terms of time since they held the ball for the final 13 minutes last year against the Seahawks. Their previous long drive this year consumed 7:08 and ended with a field goal vs. Miami on Oct. 30.
*Manning completed 26 of 40 passes for 311 yards, two touchdowns and two interceptions. The two touchdown passes increased his career total to 173, tying Charlie Conerly (1948-61) for second on the Giants' career list. Phil Simms is first with 199 touchdown passes.
*The 300-yard game was Manning's fourth of the season and the 18th of his career. That broke a tie with Kerry Collins and moved Manning into second on the Giants' list of 300-yard passers. Simms is No. 1 with 21.
*The Giants are 9-9 when Manning throws for at least 300 yards.
*Manning started his 112th consecutive regular season game, breaking a tie with Tom Brady and moving him into fourth place on the NFL's all-time list for consecutive starts by quarterbacks. Directly ahead of Manning is Ron Jaworski, who started 116 games in a row for Philadelphia from 1977-84. Brett Favre holds the record for consecutive regular season starts by a quarterback with 297. Peyton Manning is second with 208.
*The starting quarterbacks – Manning and San Francisco's Alex Smith – were the No. 1 overall selections of the 2004 and 2005 NFL Drafts.
*Manning completed his first 10 passes. It was the second time this season he completed 10 passes in a row. Manning also did it vs. St. Louis on Sept. 19.
*Manning is 3-1 against the 49ers.
*Brandon Jacobs rushed for 55 yards on 18 carries to increase his career totals to 4,531 yards and 1,004 rushing attempts. He is the fifth player in Giants history to rush for at least 4,500 yards and the sixth with at least 1,000 carries.
*Corey Webster intercepted a Smith pass late in the second quarter. It was Webster's team-leading fourth pick of the season and ties the career-high he set in 2010.
*Osi Umenyiora sacked Smith for a six-yard loss. He has 7.0 sacks in six games this season and 66.5 in his career.
*Defensive tackle Linval Joseph picked up his second sack in three games. They are the first two sacks of his career.
*The Giants played the second half without linebacker Michael Boley (hamstring) and cornerback Aaron Ross (quad contusion). Boley was replaced by rookie Spencer Paysinger and Ross by Michael Coe.
*With Ross sidelined, Victor Cruz was the punt returner. He ran back three for 12 yards, including an 11-yarder. Cruz also led the Giants with 84 receiving yards on six catches (which tied Mario Manningham).
*Rookie Da'Rel Scott assumed the kickoff return duties and had two runbacks for 53 yards, including a 37-yarder.
*Hakeem Nicks returned to action after missing last week's victory in New England with a hamstring injury. Nicks caught two passes for 41 yards, including a 32-yard touchdown in the fourth quarter.
*Center David Baas was back in the lineup after missing the Patriots game with a knee injury.
*Lawrence Tynes kicked two field goals and two extra points. Tynes now has 157 extra points as a Giant, tying him with Ben Agajanian (1949, 54-57) and Brad Daluiso (1993-2000) for the third-highest total in Giants history. Daluiso watched the game standing next to the Giants' bench area. Tynes has made 140 consecutive extra point attempts, extending his team record.
*Both Tom Coughlin and Jim Harbaugh lost replay challenges.
With 9:41 remaining in the third quarter. Steve Weatherford punted to Ted Ginn, Jr., who let the ball drop in front of him. The ball was downed by Jacquian Williams. Coughlin claimed the ball hit Ginn and should be awarded to the Giants. After review, Tony Corrente upheld the call on the field. Coughlin is 3-2 this season, 32-34 as the Giants coach and 43-43 in his career on replay challenges.
Harbaugh tried to get a call reversed with 3:25 remaining in the fourth quarter after Manningham caught an 18-yard pass on fourth-and-six. But after reviewing the play, Corrente said Manningham had gotten both feet down inbounds, which Harbaugh had challenged. Opposing coaches are 1-2 this and 20-32 on replay challenges since Coughlin joined the Giants in 2004.
*David Akers' 52-yard field goal is the longest vs. the Giants since John Kasay Sept. 12, 2010 (52 yards)
*San Francisco cornerback Carlos Rogers intercepted two Manning passes, the first Giants opponent with a pair of picks in a game since Philadelphia's Asante Samuel did it on Nov. 21, 2010.
*The Giants inactive players were running back Ahmad Bradshaw, cornerback Prince Amukamara, wide receiver Jerrel Jernigan, fullback Henry Hynoski, defensive tackle Dwayne Hendricks and offensive linemen Mitch Petrus and James Brewer.
*The Giants-Niners regular season series is tied, 14-14.
*Coughlin lost for the first time in five career games vs. the 49ers.
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