Everything you need to know heading into the Week 2 matchup between the Giants and Bills:
1. Home opener. After an unsuccessful trip to Dallas, the New York Giants return to MetLife Stadium this Sunday for their 2019 home opener. They host the AFC East's Buffalo Bills, who last week defeated the New York Jets in a comeback thriller. The Giants have won the last three (in 2007, 2011 and 2015) and four of the last five games in the series against the Bills.
2. Circling the wagons around MetLife. As of Sunday night, the Bills will have played more games in MetLife Stadium than the Giants and Jets this season. Buffalo started the year on the road against the Jets, who jumped out to a 16-0 lead only to have the Bills score 17 unanswered points. Sunday will be the first time a road team has played at the same stadium in consecutive weeks since Baltimore did it in 2016, also at MetLife Stadium.
3. Eli-0. Quarterback Eli Manning is 3-0 vs. Buffalo, one of four teams he has a perfect record against as a starter. He is 4-0 vs. Houston, 3-0 vs. Miami and 3-0 vs. Oakland. Manning last met the Bills on Oct. 4, 2015, in Buffalo, where he threw three touchdown passes in a 24-10 Giants victory. They last faced each other in New Jersey on Oct. 16, 2011, when Lawrence Tynes kicked a game-winning 23-yard field goal with 1:32 remaining in a 27-24 Giants victory.
4. Injury report. NYG – Out: WR Sterling Shepard (concussion), WR Darius Slayton (hamstring), TE Garrett Dickerson (quad). Questionable: WR Cody Latimer (calf). BUF – Out: CB Taron Johnson (hamstring), WR Andre Roberts (quad). Questionable: TE Tyler Kroft (foot).
5. Engram's growing importance. With Shepard out and Golden Tate on the second week of a four-game suspension to start the season, tight end Evan Engram again will be a focal point in the passing attack. The third-year pro caught an opening-drive touchdown last week en route to posting career highs in receptions (11) and receiving yards (116).
6. Saquon hundred. Running back Saquon Barkley needs five receptions to tie Carolina's Christian McCaffrey (18 games) as the fastest running backs in NFL history to reach 100 career receptions. Last week, Barkley recorded his 14th game with at least 100 yards from scrimmage. He ran for 120 yards on 11 carries and caught four passes for 19 yards. His first carry was a 59-yard gain in which he reached a speed of 21.76 mph, which was the NFL's fastest by a ball carrier in Week 1, according to Next Gen Stats.
View the best images from the all-time series between the Giants and Bills
7. Giants bring back TJ Jones. The Giants this week re-signed wide receiver TJ Jones, who led them in catches in the preseason but was released in the roster cut on August 31. The team created room on the roster by placing linebacker Kareem Martin on injured reserve. Martin, who played all 16 games last season, suffered a knee injury in Dallas. Jones, who spent his first four seasons in Detroit, is also an option as a return specialist.
8. Picking up the D. The Giants failed to record a sack or force a turnover last week against the Cowboys. The result was a loss for Big Blue and a perfect 158.3 passer rating for Dak Prescott, the first of its kind against the Giants with a minimum 20 pass attempts. The Giants have lost their last 11 games in which they did not force a turnover.
On the other side, Buffalo has held nine consecutive opponents to less than 210 passing yards, their longest streak since 2004 and the NFL's longest since Seattle's streak of 13 games in a row from 2013-14.
9. Next up: Josh Allen. The defense's next challenge is taking down second-year quarterback Josh Allen, who leads all players at his position in rushing touchdowns (nine) and 10-yard runs (24) since he was drafted seventh overall in 2018. The Bills are 6-1 when the former seventh overall draft pick has a rushing touchdown; they are 0-6 when he does not. The good news for Giants fans is that Allen has the third-highest interception rate (3.9% of pass attempts) in the NFL (minimum 224 attempts) since he came into the league. Ryan Fitzpatrick (4.7) is first, Jameis Winston (4.1) is second and Josh Rosen (3.8) is fourth.
10. Fantennial Kickoff. The NFL is continuing its centennial celebration with local team Fantennial Weekends. Dozens of Giants alumni will be celebrated on-field during Sunday's game, including a special halftime ceremony when the Giants will reveal the greatest moment in franchise history.